Britain launches genome database to improve patient care






LONDON (Reuters) – Up to 100,000 Britons suffering from cancer and rare diseases are to have their genetic codes fully sequenced and mapped as part of government efforts to boost drug development and improve treatment.


Britain will be the first country to introduce a database of genetic sequences into a mainstream health service, officials say, giving doctors a more advanced understanding of a patient’s illness and what drugs and other treatments they need.






It could significantly reduce the number of premature deaths from cancer within a generation, Prime Minister David Cameron‘s office said in a statement.


“By unlocking the power of DNA data, the NHS (National Health Service) will lead the global race for better tests, better drugs and above all better care,” Cameron said on Monday.


His government has set aside 100 million pounds ($ 160 million) for the project in the taxpayer-funded NHS over the next three to five years.


Harpal Kumar, chief executive of the charity Cancer Research UK, said the work would uncover new information from which doctors and scientists will learn about the biology of cancers and develop new ways to prevent, diagnose and treat them.


He said some targeted, or personalized, cancer treatments such as Novartis’ Gleevec, or imatinib – a drug for chronic myeloid leukemia – are already helping to treat patients more effectively.


Some critics of the project, known as the “UK genome plan”, have voiced concerns about how the data will be used and shared with third parties, including with commercial organizations such as drug companies.


Genewatch, a campaign group fighting for genetic science and technologies to be used in the public interest, has said anyone with access to the database could use the genetic codes to identify and track every individual on it and their relatives.


Cameron’s office said the genome sequencing would be entirely voluntary and patients would be able to opt out without affecting their NHS care. It said the data would be made anonymous before it is stored.


($ 1 = 0.6242 British pounds)


(Reporting by Kate Kelland; Editing by Stephen Powell and Tom Pfeiffer)


Medications/Drugs News Headlines – Yahoo! News


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Peru’s capital highly vulnerable to major quake












LIMA, Peru (AP) — The earthquake all but flattened colonial Lima, the shaking so violent that people tossed to the ground couldn’t get back up. Minutes later, a 50-foot (15-meter) wall of Pacific Ocean crashed into the adjacent port of Callao, killing all but 200 of its 5,000 inhabitants. Bodies washed ashore for weeks.


Plenty of earthquakes have shaken Peru‘s capital in the 266 years since that fateful night of Oct. 28, 1746, though none with anything near the violence.












The relatively long “seismic silence” means that Lima, set astride one of the most volatile ruptures in the Earth’s crust, is increasingly at risk of being hammered by a one-two, quake-tsunami punch as calamitous as what devastated Japan last year and traumatized Santiago, Chile, and its nearby coast a year earlier, seismologists say.


Yet this city of 9 million people is sorely unprepared. Its acute vulnerability, from densely clustered, unstable housing to a dearth of first-responders, is unmatched regionally. Peru’s National Civil Defense Institute forecasts up to 50,000 dead, 686,000 injured and 200,000 homes destroyed if Lima is hit by a magnitude-8.0 quake.


“In South America, it is the most at risk,” said architect Jose Sato, director of the Center for Disaster Study and Prevention, or PREDES, a non-governmental group financed by the charity Oxfam that is working on reducing Lima’s quake vulnerability.


Lima is home to a third of Peru’s population, 70 percent of its industry, 85 percent of its financial sector, its entire central government and the bulk of international commerce.


“A quake similar to what happened in Santiago would break the country economically,” said Gabriel Prado, Lima’s top official for quake preparedness. That quake had a magnitude of 8.8.


Quakes are frequent in Peru, with about 170 felt by people annually, said Hernando Tavera, director of seismology at the country’s Geophysical Institute. A big one is due, and the chances of it striking increase daily, he said. The same collision of tectonic plates responsible for the most powerful quake ever recorded, a magnitude-9.5 quake that hit Chile in 1960, occurs just off Lima’s coast, where about 3 inches of oceanic crust slides annually beneath the continent.


A 7.5-magnitude quake in 1974 a day’s drive from Lima in the Cordillera Blanca range killed about 70,000 people as landslides buried villages. Seventy-eight people died in the capital. In 2007, a 7.9-magnitude quake struck even closer, killing 596 people in the south-central coastal city of Pisco.


A shallow, direct hit is the big danger.


More than two in five Lima residents live either in rickety structures on unstable, sandy soil and wetlands that amplify a quake’s destructive power or in hillside settlements that sprang up over a generation as people fled conflict and poverty in Peru’s interior. Thousands are built of colonial-era adobe.


Most quake-prone countries have rigorous building codes to resist seismic events. In Chile, if engineers and builders don’t adhere to them they can face prison. Not so in Peru.


“People are building with adobe just as they did in the 17th century,” said Carlos Zavala, director of Lima’s Japanese-Peruvian Center for Seismic Investigation and Disaster Mitigation.


Environmental and human-made perils compound the danger.


Situated in a coastal desert, Lima gets its water from a single river, the Rimac, which a landslide could easily block. That risk is compounded by a containment pond full of toxic heavy metals from an old mine that could rupture and contaminate the Rimac, said Agustin Gonzalez, a PREDES official advising Lima’s government.


Most of Lima’s food supply arrives via a two-lane highway that parallels the river, another potential chokepoint.


Lima’s airport and seaport, the key entry points for international aid, are also vulnerable. Both are in Callao, which seismologists expect to be scoured by a 20-foot (6-meter) tsunami if a big quake is centered offshore, the most likely scenario.


Mayor Susana Villaran’s administration is Lima’s first to organize a quake-response and disaster mitigation plan. A February 2011 law obliged Peru’s municipalities to do so. Yet Lima’s remains incipient.


“How are the injured going to be attended to? What is the ability of hospitals to respond? Of basic services? Water, energy, food reserves? I don’t think this is being addressed with enough responsibility,” said Tavera of the Geophysical Institute.


By necessity, most injured will be treated where they fall, but Peru’s police have no comprehensive first-aid training. Only Lima’s 4,000 firefighters, all volunteers, have such training, as does a 1,000-officer police emergency squadron.


But because the firefighters are volunteers, a quake’s timing could influence rescue efforts.


“If you go to a fire station at 10 in the morning there’s hardly anyone there,” said Gonzalez, who advocates a full-time professional force.


In the next two months, Lima will spend nearly $ 2 million on the three fire companies that cover downtown Lima, its first direct investment in firefighters in 25 years, Prado said. The national government is spending $ 18 million citywide for 50 new fire trucks and ambulances.


But where would the ambulances go?


A 1997 study by the Pan American Health Organization found that three of Lima’s principal public hospitals would likely collapse in a major quake, but nothing has been done to reinforce them.


And there are no free beds. One public hospital, Maria Auxiliadora, serves more than 1.2 million people in Lima’s south but has just 400 beds, and they are always full.


Contingency plans call for setting up mobile hospitals in tents in city parks. But Gonzalez said only about 10,000 injured could be treated.


Water is also a worry. The fire threat to Lima is severe — from refineries to densely-backed neighborhoods honeycombed with colonial-era wood and adobe. Lima’s firefighters often can’t get enough water pressure to douse a blaze.


“We should have places where we can store water not just to put out fires but also to distribute water to the population,” said Sato, former head of the disaster mitigation department at Peru’s National Engineering University.


The city’s lone water-and-sewer utility can barely provide water to one-tenth of Lima in the best of times.


Another big concern: Lima has no emergency operations center and the radio networks of the police, firefighters and the Health Ministry, which runs city hospitals, use different frequencies, hindering effective communication.


Nearly half of the city’s schools require a detailed evaluation to determine how to reinforce them against collapse, Sato said.


A recent media blitz, along with three nationwide quake-tsunami drills this year, helped raise consciousness. The city has spent more than $ 77 million for retention walls and concrete stairs to aid evacuation in hillside neighborhoods, Prado said, but much more is needed.


At the biggest risk, apart from tsunami-vulnerable Callao, are places like Nueva Rinconada.


A treeless moonscape in the southern hills, it is a haven for economic refugees who arrive daily from Peru’s countryside and cobble together precarious homes on lots they scored into steep hillsides with pickaxes.


Engineers who have surveyed Nueva Rinconada call its upper reaches a death trap. Most residents understand this but say they have nowhere else to go.


Water arrives in tanker trucks at $ 1 per 200 liters (52 gallons) but is unsafe to drink unless boiled. There is no sanitation; people dig their own latrines. There are no streetlamps, and visibility is erased at night as Lima’s bone-chilling fog settles into the hills.


Homes of wood, adobe and straw matting rest on piled-rock foundations that engineers say will crumble and rain down on people below in a major quake.


A recently built concrete retaining wall at the valley’s head lies a block beneath the thin-walled wood home of Hilarion Lopez, a 55-year-old janitor and community leader. It might keep his house from sliding downhill, but boulders resting on uphill slopes could shake loose and crush him and his neighbors.


“We’ve made holes and poured concrete around some of the more unstable boulders,” he says, squinting uphill in a strong late morning sun.


He’s not so worried if a quake strikes during daylight.


“But if I get caught at night? How do I see a rock?”


___


Associated Press writer Franklin Briceno contributed to this report.


___


Frank Bajak on Twitter: http://twitter.com/fbajak


Latin America News Headlines – Yahoo! News


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Comedian Katt Williams arrested near Sacramento












SACRAMENTO, Calif. (AP) — Comedian Katt Williams has been arrested in northern California on a felony warrant related to a police chase.


The Sacramento Bee reports (http://bit.ly/UNq5QW ) that Williams was arrested Friday night in Dunnigan, about 25 miles north of Sacramento, by Yolo County deputies.












The paper says he was released from the county jail Saturday after posting bail.


The sheriff’s department confirmed Williams’ arrest late Saturday, but staffers on duty didn’t have details. A spokesman for the comedian didn’t immediately return a call and email.


The California Highway Patrol says Williams fled officers on a three-wheeled motorcycle on Nov. 25 after being spotted driving on a downtown Sacramento sidewalk.


The CHP said Williams was asked to stop and refused, leading to the pursuit.


The CHP says Williams nearly hit five people during the chase, which police ended for safety reasons.


Entertainment News Headlines – Yahoo! News


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Factbox: Chavez’s chosen successor Nicolas Maduro












CARACAS (Reuters) – President Hugo Chavez has named Vice President Nicolas Maduro as the heir of his self-styled socialist revolution should cancer force him out of office. He urged Venezuelans to vote for Maduro in the event of a snap election.


Here are some facts about Maduro:












* A former bus driver and trade unionist with Caracas public transport, the mustachioed Maduro, 50, has been foreign minister since 2006 and also was named vice president in October.


* As foreign minister, he has been a faithful ambassador of Chavez’s views, including often radical critiques of global affairs from a hard left-wing stance.


* Maduro has won plaudits from foreign diplomats for his affable, easygoing manner. “He’s the smoothest and least prickly of all the top Chavistas to deal with,” one European envoy said.


* Maduro has been increasingly close to Chavez since his first cancer diagnosis in mid-2011, often at his side in Havana and giving brief updates to Venezuelans, although without giving away too many details of his boss’s condition.


* Maduro’s trade union background appeals to Chavez’s working-class supporters and he is highly respected among the president’s inner circle. Past polls have shown that opposition leader Henrique Capriles would beat him in an election but analysts say that could change in a new electoral scenario given that Maduro would have Chavez’s blessing.


* Maduro was elected in 2000 as a deputy to the National Assembly, where his combative defense of Chavez’s policies made him one of the president’s favored protégés.


* He rose to become president of the legislature, and upon becoming foreign minister passed his previous post to his wife, Cilia Flores, a lawyer who became the first woman to serve as National Assembly president, between 2006 and 2011.


* When Chavez was sent to prison following his failed coup attempt in 1992, it was Flores who led the legal team that won his freedom two years later. She now serves as the country’s attorney general. She and Maduro are seen as a “power couple” in government circles.


* Chavez’ endorsement of Maduro has sidelined ambitions of other powerful Socialist Party figures such as Diosdado Cabello, who was widely considered a candidate for the top job in the future. Cabello, a military man with close ties to the armed forces and business, is not as well liked as Maduro among Venezuelans. He immediately pledged loyalty to both Chavez and the vice president after Chavez made his announcement.


(This story removed extraneous word from the first paragraph)


(Editing by Bill Trott)


Health News Headlines – Yahoo! News


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More Egypt protests called after Morsi concession


CAIRO (AP) — Egypt's liberal opposition called for more protests Sunday, seeking to keep up the momentum of its street campaign after the president made a partial concession overnight but refused its main demand he rescind a draft constitution going to a referendum on Dec. 15.


President Mohammed Morsi met one of the opposition's demands, annulling his Nov. 22 decrees that gave him near unrestricted powers. But he insisted on going ahead with the referendum on a constitution hurriedly adopted by his Islamist allies during an all-night session late last month.


The opposition National Salvation Front called on supporters to rally against the referendum. The size of Sunday's turnout, especially at Cairo's central Tahrir square and outside the presidential palace in the capital's Heliopolis district, will determine whether Morsi's concession chipped away some of the popular support for the opposition's cause.


The opposition said Morsi's rescinding of his decrees was an empty gesture since the decrees had already achieved their main aim of ensuring the adoption of the draft constitution. The edicts had barred the courts from dissolving the Constituent Assembly that passed the charter and further neutered the judiciary by making Morsi immune from its oversight.


Still, the lifting of the decrees could persuade many judges to drop their two-week strike to protest what their leaders called Morsi's assault on the judiciary. An end to their strike means they would oversee the Dec. 15 vote as is customary in Egypt.


If the referendum goes ahead, the opposition faces a new challenge — either to campaign for a "no" vote or to boycott the process altogether. A low turnout or the charter passing by a small margin of victory would cast doubts on the constitution's legitimacy.


It was the decrees that initially sparked the wave of protests against Morsi that has brought tens of thousands into the streets in past weeks. But the rushed passage of the constitution further inflamed those who feel Morsi and his Islamist allies, including the Muslim Brotherhood, are monopolizing power in Egypt and trying to force their agenda.


The draft charter was adopted amid a boycott by liberal and Christian members of the Constituent Assembly. The document would open the door to Egypt's most extensive implementation of Islamic law, enshrining a say for Muslim clerics in legislation, making civil rights subordinate to Shariah and broadly allowing the state to protect "ethics and morals." It fails to outlaw gender discrimination and mainly refers to women in relation to home and family.


Sunday's rallies would be the latest of a series by opponents and supporters of Morsi, who hails from the Muslim Brotherhood.


Both sides have drawn tens of thousands of people into the streets, sparking bouts of street battles that have left at least six people dead and hundreds wounded. Several offices of the Muslim Brotherhood also have been ransacked or torched in the unrest.


Morsi, who took office in June as Egypt's first freely elected president, rescinded the Nov. 22 decrees at the recommendation Saturday of a panel of 54 politicians and clerics who took part in a "national dialogue" the president called for to resolve the crisis. Most of the 54 were Islamists who support the president, since the opposition boycotted the dialogue.


In his overnight announcement, Morsi also declared that if the draft constitution is rejected by voters in the referendum, a nationwide election would be held to select the next Constituent Assembly.


The assembly that adopted the draft was created by parliament, which was dominated by the Brotherhood and other Islamists, and had an Islamist majority from the start. The lawmaking lower house of parliament was later disbanded by court order before Morsi's inauguration.


If the draft is approved in the referendum, elections would be held for a new lower house of parliament would be held within two months, Morsi decided.


The president has maintained all along that his Nov. 22 decrees were motivated by his desire to protect the country's state institutions and transition to democratic rule against a "conspiracy" hatched by figures of the ousted regime of Hosni Mubarak.


Morsi, whose claims have been repeated by leaders of his Brotherhood, has yet to divulge details of the alleged conspiracy.


Read More..

MiFi With Touchscreen is a Road Warrior’s Dream












Meet the Novatel MiFi Liberate: the first mobile access point with a touchscreen, letting you configure it without connecting it to a computer.


If you’re not familiar with mobile access points, these handy gadgets allow you to hook up to the Internet via cellular networks. It’s useful, often essential, if you’re in an area that has no Wi-Fi. If you’re in range of a cellular tower, this MiFi Liberate lets you connect 10 Wi-Fi devices of any kind to the Internet.












[More from Mashable: Google Considering Wireless Network [REPORT]]


Mobile access points are ideal for frequent travelers, accommodating anyone who needs to get online wherever they are. Just the fact that you’re no longer at the mercy of hotels and their Wi-Fi price-gouging makes it worth the cost of admission.


The Novatel MiFi device we tested connects to the AT&T LTE network. That resulted in spectacular upload and download speed, rivaling that of wired broadband networks. The speed of LTE is variable — depending on how many people are using it and how close you are to one of its broadcast towers — but if you’ve been limping along with 3G connectivity, you’ll probably be astonished at the difference.


[More from Mashable: Samsung Galaxy Camera Goes on Sale Nov. 16]


How fast was this MiFi Liberate? We took multiple readings in a variety of locations. It averaged a zippy 19.70 Mbps for downloads, and a tremendous 20.66 Mbps for uploads. That kind of speed can make a big difference in your work, especially if you’re dealing with large files. In many ways, though, that’s more of a testament to the speed of AT&T’s network, rather than the alacrity of this particular device. Your mileage may vary.


Lovely Touchscreen


The best new feature of this device is its excellent 2.8-inch LCD capacitive touchscreen, the first of its kind. It responds to the slightest touch, letting you easily wander around its menus. And even while using that gorgeous screen, it still has in excess of 10 hours of battery life per charge.


That screen can come in handy in unexpected ways. For example, we were impressed with the way it indicated when a device has connected. Once it has, you can drill down farther, finding out more about that device. The screen adjusts for orientation, righting itself when you turn it upside down just like smartphones do.


If you and others are connected to this MiFi unit, it lets you share movies, photos and music via DLNA, with all of you accessing content on a microSD card inserted into the side of this versatile gadget.


It’s Expensive


All that versatility and convenience doesn’t come cheap. While the MiFi Liberate costs $ 49.99 with a two-year contract, you’ll also need to pay a monthly tariff for your LTE connectivity. Because of its blazing speed, we’re thinking you might want to spring for the 5 GB a month plan for $ 50 from AT&T. That takes the MiFi Liberate out of the value-priced category, and into one that you hope your boss will be willing to pay for.


After spending a couple of weeks with this unit, it was easy to conclude that the Novatel MiFi Liberate is the best portable access point we’ve ever tested.


If you need connectivity on the go at the fastest possible speed, this one will do the trick. And if you want to observe and adjust the unit on a bright and responsive touchscreen, look no further.


MiFi Liberate, Side View


It’s nice and small, except for that bulge, which contains a changeable lithium-ion battery.


Click here to view this gallery.


This story originally published on Mashable here.


Tech News Headlines – Yahoo! News


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More Egypt protests called after Morsi concession


CAIRO (AP) — Egypt's liberal opposition called for more protests Sunday, seeking to keep up the momentum of its street campaign after the president made a partial concession overnight but refused its main demand he rescind a draft constitution going to a referendum on Dec. 15.


President Mohammed Morsi met one of the opposition's demands, annulling his Nov. 22 decrees that gave him near unrestricted powers. But he insisted on going ahead with the referendum on a constitution hurriedly adopted by his Islamist allies during an all-night session late last month.


The opposition National Salvation Front called on supporters to rally against the referendum. The size of Sunday's turnout, especially at Cairo's central Tahrir square and outside the presidential palace in the capital's Heliopolis district, will determine whether Morsi's concession chipped away some of the popular support for the opposition's cause.


The opposition said Morsi's rescinding of his decrees was an empty gesture since the decrees had already achieved their main aim of ensuring the adoption of the draft constitution. The edicts had barred the courts from dissolving the Constituent Assembly that passed the charter and further neutered the judiciary by making Morsi immune from its oversight.


Still, the lifting of the decrees could persuade many judges to drop their two-week strike to protest what their leaders called Morsi's assault on the judiciary. An end to their strike means they would oversee the Dec. 15 vote as is customary in Egypt.


If the referendum goes ahead, the opposition faces a new challenge — either to campaign for a "no" vote or to boycott the process altogether. A low turnout or the charter passing by a small margin of victory would cast doubts on the constitution's legitimacy.


It was the decrees that initially sparked the wave of protests against Morsi that has brought tens of thousands into the streets in past weeks. But the rushed passage of the constitution further inflamed those who feel Morsi and his Islamist allies, including the Muslim Brotherhood, are monopolizing power in Egypt and trying to force their agenda.


The draft charter was adopted amid a boycott by liberal and Christian members of the Constituent Assembly. The document would open the door to Egypt's most extensive implementation of Islamic law, enshrining a say for Muslim clerics in legislation, making civil rights subordinate to Shariah and broadly allowing the state to protect "ethics and morals." It fails to outlaw gender discrimination and mainly refers to women in relation to home and family.


Sunday's rallies would be the latest of a series by opponents and supporters of Morsi, who hails from the Muslim Brotherhood.


Both sides have drawn tens of thousands of people into the streets, sparking bouts of street battles that have left at least six people dead and hundreds wounded. Several offices of the Muslim Brotherhood also have been ransacked or torched in the unrest.


Morsi, who took office in June as Egypt's first freely elected president, rescinded the Nov. 22 decrees at the recommendation Saturday of a panel of 54 politicians and clerics who took part in a "national dialogue" the president called for to resolve the crisis. Most of the 54 were Islamists who support the president, since the opposition boycotted the dialogue.


In his overnight announcement, Morsi also declared that if the draft constitution is rejected by voters in the referendum, a nationwide election would be held to select the next Constituent Assembly.


The assembly that adopted the draft was created by parliament, which was dominated by the Brotherhood and other Islamists, and had an Islamist majority from the start. The lawmaking lower house of parliament was later disbanded by court order before Morsi's inauguration.


If the draft is approved in the referendum, elections would be held for a new lower house of parliament would be held within two months, Morsi decided.


The president has maintained all along that his Nov. 22 decrees were motivated by his desire to protect the country's state institutions and transition to democratic rule against a "conspiracy" hatched by figures of the ousted regime of Hosni Mubarak.


Morsi, whose claims have been repeated by leaders of his Brotherhood, has yet to divulge details of the alleged conspiracy.


Read More..

Rick Ross cancels shows after gang threats












NEW YORK (TheWrap.com) – Rick Ross has canceled two shows in North Carolina after a gang named Gangster Disciples published a series of YouTube videos threatening the Southern rapper.


Ross, a solo artist, is the founder of Maybach Music Group, a record label that release albums through Warner Bros Records. He was set to perform with fellow Maybach artists Wale, Meek Mill and Machine Gun Kelly in Greensboro on Friday and Charlotte on Saturday. A quick look at the Ticketmaster page evinces that Live Nation has canceled the shows, but a Live Nation spokeswoman did not immediately respond to a request for comment.












Various sects of the Gangster Disciples (GDs), a gang founded on the South Side of Chicago, appear in videos on YouTube threatening Ross and asking him for money. A nearly 10-minute video published recently featuring members of the North Carolina crew is titled “Rick Ross In Trouble with the GD’s North Carolina.”


They claim to have already given Ross a pass “for using our honorable chairman’s name in a disorderly fashion – a dishonest fashion.” That courtesy is over, and they know where Ross will be, mentioning Greensboro and Charlotte. They then say when they catch him in his Maybach his “time is through” and that Ross should know his penalty.


Some of the conflict seems to arise out of a reference to Gangster Disciples’ leader Larry Hoover in Ross’ song “B.M.F (Blowin Money Fast)” – hence the comment about “our honorable chairman.”


Others have said it is not about Hoover and the GDs also appear to be upset that Ross has been acting like more of a gangster than he really is. Affiliated groups, such as ones in Florida and Georgia, have made their displeasure known on YouTube and demanded money.


“We need that cash now, we need that cash – now. We need that cash right now,” one man says in a video from a Florida sect.


“We coming to you as a man William, he adds. “As a man, you supposed to honor your obligations. Therefore you going to do so. Until you do, you going to deal with the mob.”


While both those shows have been canceled, a Sunday show in Nashville, Tenn. remains on schedule.


Music News Headlines – Yahoo! News


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Peru’s capital highly vulnerable to major quake












LIMA, Peru (AP) — The earthquake all but flattened colonial Lima, the shaking so violent that people tossed to the ground couldn’t get back up. Minutes later, a 50-foot (15-meter) wall of Pacific Ocean crashed into the adjacent port of Callao, killing all but 200 of its 5,000 inhabitants. Bodies washed ashore for weeks.


Plenty of earthquakes have shaken Peru‘s capital in the 266 years since that fateful night of Oct. 28, 1746, though none with anything near the violence.












The relatively long “seismic silence” means that Lima, set astride one of the most volatile ruptures in the Earth’s crust, is increasingly at risk of being hammered by a one-two, quake-tsunami punch as calamitous as what devastated Japan last year and traumatized Santiago, Chile, and its nearby coast a year earlier, seismologists say.


Yet this city of 9 million people is sorely unprepared. Its acute vulnerability, from densely clustered, unstable housing to a dearth of first-responders, is unmatched regionally. Peru’s National Civil Defense Institute forecasts up to 50,000 dead, 686,000 injured and 200,000 homes destroyed if Lima is hit by a magnitude-8.0 quake.


“In South America, it is the most at risk,” said architect Jose Sato, director of the Center for Disaster Study and Prevention, or PREDES, a non-governmental group financed by the charity Oxfam that is working on reducing Lima’s quake vulnerability.


Lima is home to a third of Peru’s population, 70 percent of its industry, 85 percent of its financial sector, its entire central government and the bulk of international commerce.


“A quake similar to what happened in Santiago would break the country economically,” said Gabriel Prado, Lima’s top official for quake preparedness. That quake had a magnitude of 8.8.


Quakes are frequent in Peru, with about 170 felt by people annually, said Hernando Tavera, director of seismology at the country’s Geophysical Institute. A big one is due, and the chances of it striking increase daily, he said. The same collision of tectonic plates responsible for the most powerful quake ever recorded, a magnitude-9.5 quake that hit Chile in 1960, occurs just off Lima’s coast, where about 3 inches of oceanic crust slides annually beneath the continent.


A 7.5-magnitude quake in 1974 a day’s drive from Lima in the Cordillera Blanca range killed about 70,000 people as landslides buried villages. Seventy-eight people died in the capital. In 2007, a 7.9-magnitude quake struck even closer, killing 596 people in the south-central coastal city of Pisco.


A shallow, direct hit is the big danger.


More than two in five Lima residents live either in rickety structures on unstable, sandy soil and wetlands that amplify a quake’s destructive power or in hillside settlements that sprang up over a generation as people fled conflict and poverty in Peru’s interior. Thousands are built of colonial-era adobe.


Most quake-prone countries have rigorous building codes to resist seismic events. In Chile, if engineers and builders don’t adhere to them they can face prison. Not so in Peru.


“People are building with adobe just as they did in the 17th century,” said Carlos Zavala, director of Lima’s Japanese-Peruvian Center for Seismic Investigation and Disaster Mitigation.


Environmental and human-made perils compound the danger.


Situated in a coastal desert, Lima gets its water from a single river, the Rimac, which a landslide could easily block. That risk is compounded by a containment pond full of toxic heavy metals from an old mine that could rupture and contaminate the Rimac, said Agustin Gonzalez, a PREDES official advising Lima’s government.


Most of Lima’s food supply arrives via a two-lane highway that parallels the river, another potential chokepoint.


Lima’s airport and seaport, the key entry points for international aid, are also vulnerable. Both are in Callao, which seismologists expect to be scoured by a 20-foot (6-meter) tsunami if a big quake is centered offshore, the most likely scenario.


Mayor Susana Villaran’s administration is Lima’s first to organize a quake-response and disaster mitigation plan. A February 2011 law obliged Peru’s municipalities to do so. Yet Lima’s remains incipient.


“How are the injured going to be attended to? What is the ability of hospitals to respond? Of basic services? Water, energy, food reserves? I don’t think this is being addressed with enough responsibility,” said Tavera of the Geophysical Institute.


By necessity, most injured will be treated where they fall, but Peru’s police have no comprehensive first-aid training. Only Lima’s 4,000 firefighters, all volunteers, have such training, as does a 1,000-officer police emergency squadron.


But because the firefighters are volunteers, a quake’s timing could influence rescue efforts.


“If you go to a fire station at 10 in the morning there’s hardly anyone there,” said Gonzalez, who advocates a full-time professional force.


In the next two months, Lima will spend nearly $ 2 million on the three fire companies that cover downtown Lima, its first direct investment in firefighters in 25 years, Prado said. The national government is spending $ 18 million citywide for 50 new fire trucks and ambulances.


But where would the ambulances go?


A 1997 study by the Pan American Health Organization found that three of Lima’s principal public hospitals would likely collapse in a major quake, but nothing has been done to reinforce them.


And there are no free beds. One public hospital, Maria Auxiliadora, serves more than 1.2 million people in Lima’s south but has just 400 beds, and they are always full.


Contingency plans call for setting up mobile hospitals in tents in city parks. But Gonzalez said only about 10,000 injured could be treated.


Water is also a worry. The fire threat to Lima is severe — from refineries to densely-backed neighborhoods honeycombed with colonial-era wood and adobe. Lima’s firefighters often can’t get enough water pressure to douse a blaze.


“We should have places where we can store water not just to put out fires but also to distribute water to the population,” said Sato, former head of the disaster mitigation department at Peru’s National Engineering University.


The city’s lone water-and-sewer utility can barely provide water to one-tenth of Lima in the best of times.


Another big concern: Lima has no emergency operations center and the radio networks of the police, firefighters and the Health Ministry, which runs city hospitals, use different frequencies, hindering effective communication.


Nearly half of the city’s schools require a detailed evaluation to determine how to reinforce them against collapse, Sato said.


A recent media blitz, along with three nationwide quake-tsunami drills this year, helped raise consciousness. The city has spent more than $ 77 million for retention walls and concrete stairs to aid evacuation in hillside neighborhoods, Prado said, but much more is needed.


At the biggest risk, apart from tsunami-vulnerable Callao, are places like Nueva Rinconada.


A treeless moonscape in the southern hills, it is a haven for economic refugees who arrive daily from Peru’s countryside and cobble together precarious homes on lots they scored into steep hillsides with pickaxes.


Engineers who have surveyed Nueva Rinconada call its upper reaches a death trap. Most residents understand this but say they have nowhere else to go.


Water arrives in tanker trucks at $ 1 per 200 liters (52 gallons) but is unsafe to drink unless boiled. There is no sanitation; people dig their own latrines. There are no streetlamps, and visibility is erased at night as Lima’s bone-chilling fog settles into the hills.


Homes of wood, adobe and straw matting rest on piled-rock foundations that engineers say will crumble and rain down on people below in a major quake.


A recently built concrete retaining wall at the valley’s head lies a block beneath the thin-walled wood home of Hilarion Lopez, a 55-year-old janitor and community leader. It might keep his house from sliding downhill, but boulders resting on uphill slopes could shake loose and crush him and his neighbors.


“We’ve made holes and poured concrete around some of the more unstable boulders,” he says, squinting uphill in a strong late morning sun.


He’s not so worried if a quake strikes during daylight.


“But if I get caught at night? How do I see a rock?”


___


Associated Press writer Franklin Briceno contributed to this report.


___


Frank Bajak on Twitter: http://twitter.com/fbajak


Latin America News Headlines – Yahoo! News


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Ariad drug proves effective in curbing chronic leukemia in study












(Reuters) – An experimental leukemia drug from Ariad Pharmaceuticals Inc eliminated the cancer from the bone marrow of nearly half of patients with a chronic form of the disease who had stopped responding to other drugs, according to a 12-month follow-up of a pivotal drug trial.


The trial of the drug, ponatinib, which involved 444 patients, including 267 with chronic myeloid leukemia who had previously been treated with older drugs, also showed that 56 percent of chronic patients achieved the study’s goal of a “major response,” meaning the disease had nearly disappeared from the bone marrow.












Ariad earlier this year presented interim results from the trial, and U.S. Food and Drug Administration agreed in October to an expedited review. The agency is slated to decide by March 27 whether to approve ponatinib.


“We expect FDA approval sometime in the first quarter,” said Tim Clackson, Ariad’s chief scientific officer. He said the company is prepared to immediately launch sales of the drug. “We believe the overall trial data suggests activity in all forms of resistant disease.”


Ponatinib is designed to target an abnormal tyrosine kinase that is closely associated with chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia.


Ariad is also testing the drug in newly diagnosed CML patients. Final results from that trial are expected at the end of 2014, but an interim analysis will occur after half of the trial patients are enrolled, Clackson said.


Around 5,000 U.S. patients are diagnosed with CML each year, and about 2,500 patients will become resistant to their treatment, according to Ariad.


(Reporting By Deena Beasley; Editing by Leslie Adler)


Health News Headlines – Yahoo! News


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