Biogen says Lou Gehrig’s disease drug fails in trial






(Reuters) – An experimental drug to combat amyotrophic lateral sclerosis, commonly called Lou Gehrig‘s disease in the United States, failed to work in an important trial and Biogen Idec said it would stop development of the treatment.


The drug, dexpramipexole, had shown promise and seemed to work against ALS in a mid-stage clinical trial in 2011.






Biogen shares fell 6 percent in premarket trading on Thursday.


ALS is a disease of nerve cells in the brain and spinal cord that affects about 30,000 Americans, according to the ALS Association. About 5,600 Americans are diagnosed with the disease each year. American baseball player Henry Louis “Lou” Gehrig died of the disease in 1941.


There is currently only one drug that is used to help people with ALS – Rilutek, or riluzole, made by Sanofi. It has been shown to prolong the life of people with ALS, who have a life expectancy of two to five years after diagnosis.


The news was an uncommon blow for a company that has excelled in recent years and could push shares down about 10 percent, Mark Schoenebaum, a biotech analyst at ISI Group, said in an early research note.


He said analysts had estimated sales for the drug in 2016 of about $ 350 million – or about 4 percent of Biogen revenue.


The late-stage dexpramipexole trial, which was called Empower and enrolled 943 people with ALS at 81 sites in 11 countries, did not show that the drug increased the ability of people with the disease to function or improved their survival rates.


“We share the disappointment of members of the ALS community, who had hoped that dexpramipexole would offer a meaningful new treatment option,” Biogen Executive Vice President of Research and Development Douglas Williams said in a statement.


The company said it would continue to work on potential treatments for the disease.


(Reporting by Caroline Humer in New York and Esha Dey in Bangalore; Editing by Roshni Menon, Nick Zieminski and John Wallace)


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Israeli-Palestinian clashes erupt in West Bank






TAMOUN, West Bank (AP) — An arrest raid by undercover Israeli soldiers disguised as vegetable vendors ignited rare clashes in the northern West Bank on Tuesday, residents said, leaving at 10 Palestinians wounded.


Israeli army raids into Palestinian areas to seize activists and militants are fairly common. The raids are normally coordinated with Palestinian security forces, and suspects are usually apprehended without violence.






The clashes began early Tuesday after Israeli forces disguised as merchants in a vegetable truck arrested one man. Regular army forces then entered the town, prompting youths to hurl rocks to try to prevent more arrests.


Israeli forces fired tear gas, rubber bullets and live ammunition as youths set tires and bins on fire to block the passage of military vehicles. In several hours of clashes, dozens of masked youths hid behind makeshift barriers, hurling rocks and firebombs at soldiers.


Faris Bisharat, a resident of Tamoun, said 10 men were wounded, some by live fire. Bisharat said the wanted men belong to Islamic Jihad, a violent group sworn to Israel’s destruction. It wasn’t clear how many men Israeli forces sought to arrest. There were no immediate details on how seriously the 10 were hurt.


The Israeli military said it arrested a “terrorist affiliated with the Islamic Jihad terror group.” It said two soldiers were injured during the raid.


The fighting, which broke out in several parts of the town of some 8,000 people, were a rare, angry response. It was also unusual for Israeli forces to use live fire toward Palestinian demonstrators. Israel says it uses live fire only in extremely dangerous situations.


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Jon Stewart to host Grammy’s MusiCares tribute






LOS ANGELES (AP) — Jon Stewart is hosting the MusiCares salute to Bruce Springsteen.


The Recording Academy also announced Wednesday that Elton John, Neil Young, Mumford & Sons, Sting, Mavis Staples and Kenny Chesney will be among more than a dozen performers who will help pay tribute to Springsteen during the Feb. 8 benefit concert, held in Los Angeles two days before the Grammy Awards.






Springsteen is MusiCare’s person of the year, an award given to a performer who is notable both artistically and philanthropically. The sold-out concert will benefit MusiCare’s emergency financial assistance and addiction recovery programs.


Other performers scheduled to appear include Juanes, Tim McGraw and Faith Hill, Jackson Browne and Alabama Shakes.


Stewart is the host of Comedy Central’s “The Daily Show With Jon Stewart.”


___


Online:


http://grammy.com


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Mandela’s recovery “on track” at home: South African government






JOHANNESBURG (Reuters) – Former South African President Nelson Mandela‘s recovery is ‘on track’ at his home in Johannesburg, the government said on Wednesday in its first statement since the anti-apartheid hero was released from hospital a week ago.


Mandela, 94, who has been in frail health for several years, spent nearly three weeks in a Pretoria hospital in December for treatment of a lung infection and surgery to remove gallstones, his longest stay for medical care since his release from prison in 1990.






“Madiba’s recovery continues on track,” presidency spokesman Mac Maharaj said referring to Mandela by his clan name.


“We are now in the phase where if we do not hear from his doctors, we assume he is all right,” he said, without giving details on Mandela’s condition.


Mandela has been receiving what the government calls “home-based high care” at his residence in an upscale Johannesburg neighborhood.


Mandela became South Africa‘s first black president after the first all-race elections in 1994, serving a five-year term.


He has been mostly absent from the political scene for the past several years due to poor health, while questions have been raised as to whether his ruling African National Congress (ANC) has lost the moral compass he left behind.


Under such leaders as Mandela, Walter Sisulu and Oliver Tambo, the ANC gained a stellar global reputation. Once the yoke of apartheid was thrown off, it began ruling South Africa in a blaze of goodwill from world leaders who viewed it as a beacon for a troubled continent and world.


Close to two decades later, this image has dimmed as critics inside and outside the country, and in the movement itself, accuse ANC leaders of indulging in the spoils of office, squandering mineral resources and engaging in power struggles.


Mandela’s “Rainbow Nation” of reconciliation has come under strain under President Jacob Zuma, a Zulu traditionalist with a history of racially charged comments, including a statement in December where he reportedly said dog ownership was for whites and not part of African culture.


Nobel Peace Prize laureate Mandela has a history of lung problems dating back to when he contracted tuberculosis as a political prisoner. He spent 27 years in prison, including 18 years on the windswept Robben Island off Cape Town.


Mandela was also admitted to hospital in February because of abdominal pain but released the following day after a keyhole examination showed there was nothing seriously wrong with him.


He has spent most of his time since then in another home in Qunu, his ancestral village in the impoverished Eastern Cape province.


His poor health has prevented him from making public appearances in the past two years, although he has continued to receive high-profile visitors, including former U.S. President Bill Clinton.


(Reporting by Jon Herskovitz; Editing by Janet Lawrence)


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Despite deal, taxes will rise for most


WASHINGTON (AP) — While the tax package that Congress passed New Year's Day will protect 99 percent of Americans from an income tax increase, most of them will still end up paying more federal taxes in 2013.


That's because the legislation did nothing to prevent a temporary reduction in the Social Security payroll tax from expiring. In 2012, that 2-percentage-point cut in the payroll tax was worth about $1,000 to a worker making $50,000 a year.


The Tax Policy Center, a nonpartisan Washington research group, estimates that 77 percent of American households will face higher federal taxes in 2013 under the agreement negotiated between President Barack Obama and Senate Republicans. High-income families will feel the biggest tax increases, but many middle- and low-income families will pay higher taxes too.


Households making between $40,000 and $50,000 will face an average tax increase of $579 in 2013, according to the Tax Policy Center's analysis. Households making between $50,000 and $75,000 will face an average tax increase of $822.


"For most people, it's just the payroll tax," said Roberton Williams, a senior fellow at the Tax Policy Center.


The tax increases could be a lot higher. A huge package of tax cuts first enacted under President George W. Bush was scheduled to expire Tuesday as part of the "fiscal cliff." The Bush-era tax cuts lowered taxes for families at every income level, reduced investment taxes and the estate tax, and enhanced a number of tax credits, including a $1,000-per-child credit.


The package passed Tuesday by the Senate and House extends most the Bush-era tax cuts for individuals making less than $400,000 and married couples making less than $450,000.


Obama said the deal "protects 98 percent of Americans and 97 percent of small business owners from a middle-class tax hike. While neither Democrats nor Republicans got everything they wanted, this agreement is the right thing to do for our country."


The income threshold covers more than 99 percent of all households, exceeding Obama's claim, according to the Tax Policy Center. However, the increase in payroll taxes will hit nearly every wage earner.


Social Security is financed by a 12.4 percent tax on wages up to $113,700, with employers paying half and workers paying the other half. Obama and Congress reduced the share paid by workers from 6.2 percent to 4.2 percent for 2011 and 2012, saving a typical family about $1,000 a year.


Obama pushed hard to enact the payroll tax cut for 2011 and to extend it through 2012. But it was never fully embraced by either party, and this time around, there was general agreement to let it expire.


The new tax package would increase the income tax rate from 35 percent to 39.6 percent on income above $400,000 for individuals and $450,000 for married couples. Investment taxes would increase for people who fall in the new top tax bracket.


High-income families will also pay higher taxes this year as part of Obama's 2010 health care law. As part of that law, a new 3.8 percent tax is being imposed on investment income for individuals making more than $200,000 a year and couples making more than $250,000.


Together, the new tax package and Obama's health care law will produce significant tax increases for many high-income families.


For 2013, households making between $500,000 and $1 million would get an average tax increase of $14,812, according to the Tax Policy Center analysis. Households making more than $1 million would get an average tax increase of $170,341.


"If you're rich, you're almost certain to get a big tax increase," Williams said.


___


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Tax deal in place to avert fiscal cliff, Congress gets ready for fights


WASHINGTON (AP) — Congress' excruciating, extraordinary New Year's Day approval of a compromise averting a prolonged tumble off the fiscal cliff hands President Barack Obama most of the tax boosts on the rich that he campaigned on. It also prevents House Republicans from facing blame for blocking tax cuts for most American households, though most GOP lawmakers parted ways with Speaker John Boehner and opposed the measure.


Passage also lays the groundwork for future battles between the two sides over federal spending and debt.


Capping a holiday season political spectacle that featured enough high and low notes for a Broadway musical, the GOP-run House voted final approval for the measure by 257-167 late Tuesday. That came after the Democratic-led Senate used a wee-hours 89-8 roll call to assent to the bill, belying the partisan brinkmanship that colored much of the path to the final deal.


"A central promise of my campaign for president was to change the tax code that was too skewed towards the wealthy at the expense of working middle-class Americans," Obama said at the White House before flying to Hawaii to resume his holiday break. "Tonight we've done that."


The bill would boost the top 35 percent income tax rate to 39.6 percent for incomes exceeding $400,000 for individuals and $450,000 for couples, while continuing decade-old income tax cuts for everyone else. In his re-election campaign last year Obama had vowed to boost rates on earnings at somewhat lower levels — $200,000 for individuals and $250,000 for families.


Scores of GOP lawmakers voted for the measure, reversing a quarter-century of solid Republican opposition to boosting any tax rates at all.


The bill would also raise taxes top earners pay on dividends, capital gains and inherited estates; permanently stop the alternative minimum tax from raising levies on millions of middle-income families; extend expiring jobless benefits; prevent cuts in Medicare reimbursements to doctors; and delay for two months billions in budget-wide cuts in defense and domestic programs slated for this year.


Both sides lamented their failure to reach a significant deficit-cutting agreement. But neither much mentioned another omission: The immediate expiration of a two-year, 2-percentage-point cut in the Social Security payroll tax.


That break, which put an extra $1,000 in the wallets of typical families earning $50,000 a year, was an Obama priority two years ago as a way to boost consumer spending and spark the flagging economy, but it fell victim this time to other priorities.


House Democrats voted by an overwhelming 172-16 for the agreement, which was crafted over the weekend by Senate Minority Leader Mitch McConnell, R-Ky., and Vice President Joe Biden.


But Republicans tilted against it 151-85. It is rare for leaders to bring a bill to the House floor that will be opposed by most lawmakers from their own party, and the decision underscored the pressure GOP leaders felt to approve the legislation.


Boehner, R-Ohio, took no public stance on the measure before the vote. But he guided the compromise to the House floor after an unsuccessful attempt by many conservatives to persuade leaders to add spending cuts to the bill.


Had the House inserted those budget cuts and the Senate refused to consider them, the legislation could have died. That left House Republicans worried that voters might blame them for a huge, sweeping tax increase and for any swoon the nation's financial markets might take when they reopened Wednesday.


"You can be right and you can be dead right. Which is it?" said Rep. Rich Nugent, R-Fla., of the quandary Republicans faced. "Right now you need to take the tax issue off the table" and move on to a focus on curbing spending, he said.


Boehner voted for the bill, an unusual step because speakers seldom vote, and he was joined by Rep. Paul Ryan, R-Wis., the GOP's vice presidential candidate last fall. Voting "no" were the other two top GOP leaders, Reps. Eric Cantor of Virginia and Kevin McCarthy of California.


Passage came nearly 24 hours after a decade's worth of tax cuts enjoyed by tens of millions of Americans expired with the stroke of the new year, technically raising taxes by more than $500 billion in 2013 alone.


Those tax increases — plus $109 billion in defense and domestic spending cuts that were to be automatically triggered Wednesday — became known as the fiscal cliff. Economists warned that their combined impact would hurl the economy back into recession, but Obama's signature on the bill would prevent the "cliff" from taking hold.


Obama can sign the bill remotely using a machine called an "autopen," or the bill can be flown to Hawaii for his signature.


Overall, the legislation would add nearly $4 trillion to federal deficits over the next decade compared with what would have happened had all the tax cuts expired, according to the nonpartisan Congressional Budget Office.


"I'm embarrassed for this generation. Future generations deserve better," complained one foe, Rep. Louie Gohmert, R-Texas.


The agreement's journey to passage was a tortured one. It included negotiations between Obama and Boehner on a larger, deficit-cutting deal that collapsed, and a failed effort by the speaker to drum up enough GOP votes to pass a "Plan B" that would have limited tax boosts to incomes exceeding $1 million.


It took weekend talks between McConnell and Biden, former Senate colleagues, to craft the more modest package that focused on averting the worst impacts of the fiscal cliff while postponing any deficit reduction efforts to coming months.


Those first showdowns will come over the next three months, when the government's legal ability to borrow money will expire and temporary financing for federal agency budgets will expire. Republicans have already said that, as they did in 2011, they will demand spending cuts as a condition for extending the debt ceiling.


"Now the focus turns to spending" and overhauling the tax code, Boehner said in a written statement after the vote. He said the GOP will fight for "significant spending cuts and reforms to the entitlement programs that are driving our country deeper and deeper into debt," a reference to costly benefit programs like Medicare, Social Security and Medicaid.


Spending cuts are "going to be a component of every single battle we have" in the new Congress, conservative GOP Rep. Marsha Blackburn of Tennessee told CNN on Wednesday.


Obama, in his White House remarks, said that while he was open to compromise, he would demand deficit-cutting savings from added revenue on the well-off, not just spending cuts.


He also pointedly said he would "not have another debate with this Congress" over extending the federal borrowing limit.


"If Congress refuses to give the United States government the ability to pay these bills on time, the consequences for the entire global economy would be catastrophic — far worse than the impact of a fiscal cliff," he said.


Though its focus was on taxes, the measure approved Tuesday would prevent a potential doubling of milk prices and prevent a $900 salary increase for members of Congress in March. Its extension of jobless benefits would help 2 million people out of work at least six months, and it would prevent a 27 percent cut in reimbursements doctors get for treating Medicare patients.


Weighing in with criticism of the compromise were the chief authors of an influential bipartisan deficit-cutting proposal, former GOP Sen. Alan Simpson and Democrat Erskine Bowles, a former White House chief of staff under President Bill Clinton. They called the measure "truly a missed opportunity to do something big to reduce our long term fiscal problems."


___


AP reporters David Espo, Charles Babington, Andrew Taylor and Larry Margasak contributed to this report.


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Low-cost Chinese film sets new record






BEIJING (AP) — A low-budget, domestically produced comedy has unexpectedly become the highest-grossing Chinese film to date.


Chinese state media say the wacky road movie “Lost in Thailand” has grossed more than 1 billion yuan ($ 160 million) since its Dec. 12 debut. The official Xinhua News Agency, citing an independent monitor of box office figures, said Wednesday that it also beat James Cameron‘s “Titanic” in 3-D, the most popular foreign film in 2012, in Chinese theaters.






Set in Thailand, the film tells the story of two businessmen who go searching for their boss in the north, and then link up with a tourist eager to explore the country. It is filled with slapstick humor and action scenes.


The previous record for a domestic film was 726 million yuan set by “Painted Skin 2.”


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Israeli-Palestinian clashes erupt in West Bank






TAMOUN, West Bank (AP) — An arrest raid by undercover Israeli soldiers disguised as vegetable vendors ignited rare clashes in the northern West Bank on Tuesday, residents said, leaving at 10 Palestinians wounded.


Israeli army raids into Palestinian areas to seize activists and militants are fairly common. The raids are normally coordinated with Palestinian security forces, and suspects are usually apprehended without violence.






The clashes began early Tuesday after Israeli forces disguised as merchants in a vegetable truck arrested one man. Regular army forces then entered the town, prompting youths to hurl rocks to try to prevent more arrests.


Israeli forces fired tear gas, rubber bullets and live ammunition as youths set tires and bins on fire to block the passage of military vehicles. In several hours of clashes, dozens of masked youths hid behind makeshift barriers, hurling rocks and firebombs at soldiers.


Faris Bisharat, a resident of Tamoun, said 10 men were wounded, some by live fire. Bisharat said the wanted men belong to Islamic Jihad, a violent group sworn to Israel’s destruction. It wasn’t clear how many men Israeli forces sought to arrest. There were no immediate details on how seriously the 10 were hurt.


The Israeli military said it arrested a “terrorist affiliated with the Islamic Jihad terror group.” It said two soldiers were injured during the raid.


The fighting, which broke out in several parts of the town of some 8,000 people, were a rare, angry response. It was also unusual for Israeli forces to use live fire toward Palestinian demonstrators. Israel says it uses live fire only in extremely dangerous situations.


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Women Lose Half Their Weight: How They Did It






At 25 years old and 288 pounds, Ashley Donahoo was depressed.


“I was unhappy with my job, I was unhappy with the direction my life was going, and I had a hard time enjoying the little things that my kids wanted to do,” the 27-year-old mother of two from Pace, Fla., said. “My health was failing. My doctor told me that he didn’t think I was going to make it to 30 if I kept on [this way]. … It kept getting worse and worse.”






Donahoo was concerned, but it was her faithful husband, David, who pushed her on a path to health, starting with a walk around the block.


“His heart was breaking for me,” she said. “And he saw how unhappy I was, and he came to me and said, ‘We’re going to go for a walk.’  And I was, like, ‘No, we’re not.’”


Her husband won that battle, and on the walk, she started thinking about her own choices and future.


“The realization hit me that I made this choice.  I made this choice to get where I am right now.  So I’m going to start making a different choice,” she said.   ”I put my health and myself on back burner, and I think … it had all caught up to me.”


Jumpstart Your Weight Loss: CLICK HERE to Ask a Celebrity Trainer a Question!


Like Donahoo, Caroline Jhingory reached a similar eye-opening realization about her weight.


“I looked in the mirror one day and just realized I didn’t recognize the person that was staring back at me,” said Jhingory, 32, of Washington, D.C.


Jhingory’s struggles with her weight began early. At age 8, she weighed 120 pounds. Taunted by her peers, Jhingory was enrolled in a medical weight loss program, but it didn’t work because she would sneak junk food like candy bars.


“I found a way to be a food hustler and get whatever food I wanted,” she said. “Not only did I spend two decades of my life morbidly obese. I spent two decades of my life being taunted and teased in every environment. I never went to prom. I never had dates. I couldn’t ride a roller coaster because the safety bar wouldn’t go over my stomach.”


Jhingory remained heavy until college, when she tipped the scales at 303 pounds and started feeling self-conscious in her new environment.


“I felt like I had a moment when all these difficult experiences were a huge pause button on my life. I finally said to myself, ‘I’m tired of this. I want to have a normal life.’”


Jhingory started walking everywhere. Then, she took up a daily cardio regimen to shed the weight, and she rid her pantry of tempting snack foods she once binged on. Now 149 pounds, she has reclaimed her shape and kept off the weight.


Jhingory’s amazing transformation, along with Donahoo’s and other weight-loss success stories, were spotlighted in the “Half Their Size” feature in the latest issue of People magazine.


RELATED: Is Being Overweight Really Bad For You?


Donahoo cut out the late-night binges that brought her down and, thanks to her strong support system, lost 137 pounds. She credited her weight loss success to tracking her food and exercise on livestrong.com and running. She has run two 5Ks.


Leah Fernandez of Atlanta found herself at 251 pounds after two pregnancies. The baby weight stuck and she tended to eat emotionally.


“I wanted the food,” she said. “It made me feel good, and so I ate it.”


But it was the motivation to be there for her children that helped her turn it all around.


“Thinking about going out to the park with my kids felt like work to me, you know?  And at some point I realized that’s ridiculous. Not only am I cheating myself but I’m cheating my kids of me,” she said.


Fernandez turned to Jenny Craig in March 2011 and hasn’t looked back. Since then, she has lost half her weight by staying active with her kids and incorporating walking into her lifestyle.


“I’m getting my groove back.  Leah’s getting her groove back,” she said.


RELATED: Apps to Help With Weight-Loss Resolutions


RELATED: 329 Pound-Weight-Loss Trio Share Their Secrets


READ MORE: 138 Pound Weight Loss Changes Woman’s Life


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UPDATE 7-Tennis-Auckland Classic women’s singles round 1 results






Jan 1 (Infostrada Sports) – Results from the Auckland Classic Women’s Singles Round 1 matches on Tuesday


2-Julia Goerges (Germany) beat Anastasija Sevastova (Latvia) 6-3 6-4






Marina Erakovic (New Zealand) beat Stephanie Dubois (Canada) 6-2 6-1


1-Agnieszka Radwanska (Poland) beat Greta Arn (Hungary) 6-2 6-2


8-Mona Barthel (Germany) beat Grace Min (U.S.) 6-1 6-3


6-Yaroslava Shvedova (Kazakhstan) beat Lara Arruabarrena Vecino (Spain) 6-3 6-2


Romina Oprandi (Switzerland) beat Nudnida Luangnam (Thailand) 6-0 6-2


Heather Watson (Britain) beat 5-Sorana Cirstea (Romania) 6-3 (Cirstea retired)


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