Lilly stops rheumatoid arthritis trial for lack of efficacy






(Reuters) – Eli Lilly and Co said it will stop one of three late-stage trials of its rheumatoid arthritis (RA) drug tabalumab due to insufficient efficacy.


The decision to stop the trial came after an interim futility analysis of the study, called FLEX-M.






The trial was testing the drug in patients with moderate-to-severe RA who had an inadequate response to methotrexate therapy, which is a standard RA treatment.


The decision was not based on safety concerns, and patients currently enrolled in other tabalumab RA studies will continue treatment, Lilly said.


However, the company said it was suspending enrollment of new patients in the RA program until additional analysis from other ongoing RA studies is completed in early 2013.


The study discontinuation is expected to result in an after-tax charge of about 2 cents per share in the fourth quarter.


“The results of this study were unexpected given the data generated in earlier Phase II clinical studies of tabalumab,” Lilly’s vice president of autoimmune product development, Eiry Roberts, said.


Lilly is working on another RA drug called baricitinib, which is also getting tested for psoriasis and diabetic nephropathy.


Another autoimmune disorder drug in the company’s pipeline is ixekizumab — being tested for psoriasis and psoriatic arthritis.


(Reporting by Esha Dey in Bangalore; Editing by Joyjeet Das)


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Top 2012 searches include Whitney, PSY, Sandy






LOS ANGELES (AP) — The world’s attention wavered between the tragic and the silly in 2012, and along the way, Web surfers searched in huge numbers to find out about a royal princess, the latest iPad, and a record-breaking skydiver.


Whitney Houston was the “top trending” search of the year, according to Google Inc.’s year-end “zeitgeist” report. Google‘s 12th annual roundup is “an in-depth look at the spirit of the times as seen through the billions of searches on Google over the past year,” the company said in a blog post Wednesday.






People around the globe searched en masse for news about Houston‘s accidental drowning in a bathtub just before she was to perform at a pre-Grammy Awards party in February.


Google defines topics as “trending” when they garner a high amount of traffic over a sustained period of time.


Korean rapper PSY’s “Gangnam Style” music video trotted into second spot, a testament to his self-deprecating giddy-up dance move. The video is approaching a billion views on YouTube.


Superstorm Sandy, the damaging storm that knocked out power and flooded parts of the East Coast in the midst of a U.S. presidential campaign, was third.


The next biggest trending searches globally were a pair of threes: the iPad 3 tablet from Apple Inc. and Diablo 3, a popular video game.


Rounding out the Top 10 were Kate Middleton, who made news with scandalous photos and a royal pregnancy; the 2012 Olympics in London; Amanda Todd, a Canadian teen who was found dead of an apparent suicide in October after being bullied online; Michael Clarke Duncan, the “Green Mile” actor who died of a heart attack in September at age 54; and “BBB12,” the 12th edition of “Big Brother Brasil,” a reality show featuring scantily clad men and women living together.


Some trending people, according to Google, were:


Felix Baumgartner, an Austrian skydiver who became the first to break the sound barrier without a vehicle with a 24-mile plummet from Earth’s stratosphere;


— Jeremy Lin, the undrafted NBA star who exploded off the New York Knicks bench and sparked a wave of “Linsanity”;


Morgan Freeman, the actor whose untimely death turned out not to be true.


The Internet also continued its rise as a popular tool for spreading addictive ideas and phrases known as “memes.” Remember LOL? If you don’t know what it means by now, someone may “Laugh Out Loud” at you.


This year, Facebook said its top memes included “TBH (To Be Honest),” ”YOLO (You Only Live Once),” ”SMH (Shake My Head).” Thanks to an endlessly fascinating U.S. presidential campaign, “Big Bird” made the list after Republican candidate Mitt Romney said he might consider cutting some funds for public broadcasting.


Yahoo said its own top-searched memes for the year included “Kony 2012,” a reference to the short film and campaign against Ugandan militia leader Joseph Kony; “stingray photobomb” for an unusual vacation snapshot that went viral; and “binders full of women,” another nod to Romney for his awkward description of his search for women cabinet members as Massachusetts’ governor.


And people were happy to pass on popular Twitter posts by retweeting them. According to Twitter, the year’s most popular retweets were President Barack Obama‘s “Four more years,” and Justin Bieber’s farewell to six-year-old fan Avalanna Routh, who died of a rare form of brain cancer: “RIP Avalanna. i love you”.


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Defiant North Korea launches long-range rocket into orbit



United States officials confirm that North Korea appears to have carried out the successful launch of a long-range rocket.



The move comes as a surprise to the international community, which has consistently called on North Korea to abandon its efforts.



Less than 24 hours earlier, the North Koreans had indicated they were grappling with "technical uncertainties" that forced them to extend the launch window to Dec. 29.



The secretive regime insists its efforts are part of a peaceful space program intended to place a satellite into orbit. But the U.S. and key Asian allies believe it is a thinly disguised attempt to test an intercontinental ballistic missile aimed at furthering development of the technology needed to mount a nuclear warhead on a long-range rocket that could one day reach the U.S.



National Security Council spokesman Tom Vietor called the launch a "highly provocative act that threatens regional security."



In recent weeks even China, North Korean's only remaining ally, sent a high level delegation into Pyongyang to convey a message of constraint. Today, China expressed "regret" over the incident. In the past, China has supported North Korea's right to develop its space program.



"The action is yet another example of North Korea's pattern of irresponsible behavior," read the National Security Council statement. "The United States remains vigilant in the face of North Korean provocations and is fully committed to the security of allies in the region."



North American Aerospace Defense Command (NORAD) acknowledged the launch initiated at 9:49 a.m. local time and followed its intended trajectory, traveling south between Korea and Japan.



"At no time was the missile or the resultant debris a threat to North America," said NORAD.



Japan's emergency alert system – M-NET – recorded the rocket's flight path directly over Okinawa just after 10:00 a.m. Officials say they have located three points of debris: One in South Korea's Yellow Sea, a second location further down the country's west coast and the third point 180 miles north of the Philippines.



A South Korean military official confirmed that one of their three warships, equipped with the Aegis radar system, detected the launch. The first stage fell just below Byeonsanbando, southwest of the Korean peninsula, exactly where it was supposed to, according to the official.



Increased attention focused on North Korea in recent weeks as satellite images showed action at the Tongchang-ri launch site. But on Monday, a statement from the Korean Committee of Space Technology claimed that scientists and technicians "found a technical deficiency in the first-stage control engine module of the rocket carrying the satellite." Satellite images also revealed that a new third-stage booster was delivered to the launch pad on Saturday.



A key issue is how far the rocket traveled and whether it was able to successfully separate its second and third stage rockets. If so, the capacity to travel long distances would be greatly enhanced.



The type of rocket is believed to be the Taepodong 2 missile. The North Koreans refer to it as the Unha-3, which in Korean translates as "Galaxy-3." The same type of missile has been previously tested three times in 2006, 2009 and 2012. Each time, the rocket failed soon after launch. It is believed to have the capacity to travel a minimum of 3,400 miles. That puts it well within striking range of the western U.S.




The U.S. had mobilized four warships in the Asia-Pacific region to monitor the launch. The guided missile destroyers the USS John S. McCain, the USS Benfold and the USS Fitzgerald joined the guided missile cruiser the USS Shiloh to "reassure allies in the region" according to officials.



South Korea's president Lee Myung-bak called an emergency security meeting in response. The timing is particularly sensitive for this country which is still officially at war with North Korea.



In just one week, South Korea holds key elections and will choose a new president. North Korea's successful launch could potentially sway voters favoring either a harsher line or a return to the "Sunshine Policy" of past administrations.



Current ruling party candidate Park Geun-hye has indicated a willingness to hold talks with North Korea.



Her father, Park Chung-hee, served as the South Korean president for 16 years. He was the target of multiple assassination attempts by North Korea. One of those efforts killed his wife, Chung-hee's mother.



Park took over her mother's duties as first lady until her father was assassinated by the chief of security in 1979. She re-emerged in 1997 as an active politician and is the first female candidate to be seriously considered for president.



Her party, the Saenuridang, is a traditionally conservative group that adapts a somewhat stricter policy towards North Korea that her opponent, Moon Jae-in. As head of the Democratic United Party, he champions a more lenient approach to the South's belligerent neighbor.



In repeated breaking news announcements throughout the day North Korean state-run television celebrated the launch. "We are proud of the glorious success of our satellite technology," said the presenter. "This is a landmark achievement."



Dec. 17 marks the one year anniversary of the country's Dear Leader Kim Jong-il's death. Analysts believe his son and successor, Kim Jong-Un, is under pressure to show the world he is intent on continuing his father's "Military First" policy and demonstrate a show of strength.



While experts do not believe North Korea currently has the technology to mount a nuclear warhead, today's launch is a significant development for the closed country's new leader.

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Publisher Bonnier, Flingo partner to make Smart TV Apps






NEW YORK (TheWrap.com) – Bonnier, the publisher of magazines like Savuer and Popular Science, and Flingo, the largest publisher of apps for Smart TVs, have partnered to create a series of apps extending Bonnier’s titles onto Internet-enabled TV sets and set-tops boxes like the Roku.


Together, they will release a new app for each magazine, offering videos, images and archival content for fans. Savuer has a couple of web series, including “The Test Kitchen” which helps home chefs learn how to peel garlic or dice an onion. Those videos, currently on Saveur’s website YouTube channel, will resurface in the apps, which will be distributed for free in app markets thanks to advertising and sponsors.






Though smart TVs remain a small segment of the TV market, Bonnier believes it is an ideal platform for leading media companies to extend their brand.


“This is about going after new technologies and being at the forefront,” Sean Holzman, Bonnier’s Chief Brand Development Officer, told TheWrap. “We don’t look closely at what other publishing companies may be doing. Flingo has a universe of 15 million devices and that should double in 2013.”


The emphasis will be on video since research demonstrates that it remains the top activity, even more than gaming.


Ashwin Navin, CEO of Flingo, said that while many media companies are putting secondary titles on Internet-enabled TVs, Bonnier is using its top titles.


“Major media companies aren’t putting their crown jewels on smart TVs,” Navin told TheWrap. He added that when they measure how long users spend online with certain brands, websites register just a few minutes.


“You see 10 times that in a TV app. People are more captive and less ADD.”


TV News Headlines – Yahoo! News


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North Korea’s new leader burnishes credentials with rocket






SEOUL/TOKYO (Reuters) – North Korea successfully launched a rocket on Wednesday, boosting the credentials of its new leader and stepping up the threat the isolated and impoverished state poses to its opponents.


The rocket, which North Korea says put a weather satellite into orbit, has been labeled by the United States, South Korea and Japan as a test of technology that could one day deliver a nuclear warhead capable of hitting targets as far as the continental United States.






“The satellite has entered the planned orbit,” a North Korean television news-reader clad in traditional Korean garb triumphantly announced, after which the station played patriotic songs with the lyrics “Chosun (Korea) does what it says”.


The rocket was launched just before 10 a.m. Korea time (9 p.m. ET on Tuesday), according to defense officials in South Korea and Japan, and easily surpassed a failed April launch that flew for less than two minutes.


The North American Aerospace Defense Command (NORAD) said that it “deployed an object that appeared to achieve orbit”, the first time an independent body has verified North Korean claims.


North Korea followed what it said was a similar successful launch in 2009 with a nuclear test that prompted the United Nations Security Council to stiffen sanctions that it originally imposed in 2006 after the North’s first nuclear test.


The state is banned from developing nuclear and missile-related technology under U.N. resolutions, although Kim Jong-un, the youthful head of state who took power a year ago, is believed to have continued the state’s “military first” programs put into place by his deceased father Kim Jong-il.


North Korea lauded Wednesday’s launch as celebrating the prowess of all three Kims to rule since it was founded in 1948.


“At a time when great yearnings and reverence for Kim Jong-il pervade the whole country, its scientists and technicians brilliantly carried out his behests to launch a scientific and technological satellite in 2012, the year marking the 100th birth anniversary of President Kim Il Sung,” its KCNA news agency said.


Washington condemned Wednesday’s launch as a “provocative action” and breach of U.N. rules, while Japan’s U.N. envoy called for a Security Council meeting. However, diplomats say further tough sanctions are unlikely to be agreed at the body as China, the North’s only major ally, will oppose them.


“The international community must work in a concerted fashion to send North Korea a clear message that its violations of United Nations Security Council resolutions have consequences,” the White House said in a statement.


Japan’s likely next prime minister, Shinzo Abe, who is leading in opinion polls ahead of an election on December 16 and who is known as a North Korea hawk, called on the United Nations to adopt a resolution “strongly criticizing” Pyongyang.


BEIJING BLOCK


China had expressed “deep concern” prior to the launch which was announced a day after a top politburo member, representing new Chinese leader Xi Xinping, met Kim Jong-un in Pyongyang.


On Wednesday its tone was measured, regretting the launch but calling for restraint on possible counter-measures, in line with previous policy when it has effectively vetoed tougher sanctions.


“China believes the Security Council’s response should be cautious and moderate, protect the overall peaceful and stable situation on the Korean peninsula, and avoid an escalation of the situation,” Chinese Foreign Ministry spokesman Hong Lei told journalists.


Bruce Klingner, a Korea expert at the Heritage Foundation, told a conference call: “China has been the stumbling block to firmer U.N. action and we’ll have to see if the new leadership is any different than its predecessors.”


A senior adviser to South Korea’s president said last week it was unlikely there would be action from the U.N. and that Seoul would expect its allies to tighten sanctions unilaterally.


Kim Jong-un, believed to be 29 years old, took power when his father died on December 17 last year and experts believe the launch was intended to commemorate the first anniversary of the death.


The April launch was timed for the centennial of the birth of Kim Il Sung, the grandfather of its current ruler.


Wednesday’s success puts the North ahead of the South which has not managed to get a rocket off the ground.


“This is a considerable boost in establishing the rule of Kim Jong-un,” said Cho Min, an expert at the Korea Institute of National Unification.


There have been few indications the secretive and impoverished state, where the United Nations estimates a third of the population is malnourished, has made any advances in opening up economically over the past year.


North Korea remains reliant on minerals exports to China and remittances from tens of thousands of its people working on labor projects overseas.


The 22 million population often needs handouts from defectors who have escaped to South Korea in order to afford basic medicines.


Given the puny size of its economy – per capita income is less than $ 2,000 a year – one of the few ways the North can attract world attention is by emphasizing its military threat.


Pyongyang wants the United States to resume aid and to recognize it diplomatically, although the April launch scuppered a planned food deal.


It is believed to be some years away from developing a functioning nuclear warhead although it may have enough plutonium for around half a dozen nuclear bombs, according to nuclear experts.


The North has also been enriching uranium, which would give it a second path to nuclear weapons as it sits on vast natural uranium reserves.


“A successful launch puts North Korea closer to the capability to deploy a weaponized missile,” said Denny Roy, a senior fellow at the East-West Center in Hawaii.


“But this would still require fitting a weapon to the missile and ensuring a reasonable degree of accuracy. The North Koreans probably do not yet have a nuclear weapon small enough for a missile to carry.”


Pyongyang says that its development is part of a civil nuclear program, but has also boasted of it being a “nuclear weapons power”.


(Additional reporting by Jumin Park and Yoo Choonsik in SEOUL; David Alexander, Matt Spetalnick and Paul Eckert in WASHINGTON; Linda Sieg in TOKYO; Sui-Lee Wee in BEIJING; Rosmarie Francisco in MANILA; Writing by David Chance; Editing by Raju Gopalakrishnan)


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Gilead to buy YM BioSciences for about $465 million






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Australian prank call radio to donate profits to nurse’s family






CANBERRA (Reuters) – The Australian radio station behind a prank call to a British hospital will donate its advertising revenue until the end of the year to a fund for the family of the nurse who apparently took her own life after the stunt, the company said on Tuesday.


Southern Cross Austereo, parent company of Sydney radio station 2Day FM, said it would donate all advertising revenue, with a minimum contribution of A$ 500,000 ($ 525,000), to a memorial fund for the nurse, Jacintha Saldanha, who answered the telephone at the hospital treating Prince William’s pregnant wife, Kate.






The company has suspended the Sydney-based announcers, Mel Greig and Michael Christian, scrapped their “Hot 30″ programme and suspended advertising on the station in the wake of the Saldanha’s death. Southern Cross said it would resume advertising on its station from Thursday.


“It is a terrible tragedy and our thoughts continue to be with the family,” Southern Cross Chief Executive Officer Rhys Holleran said in a statement.


“We hope that by contributing to a memorial fund we can help to provide the Saldanha family with the support they need at this very difficult time.”


(Reporting by James Grubel; Editing by Robert Birsel)


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World Chefs: Keller shares memories, spotlight in latest book






NEW YORK (Reuters) – Thomas Keller, one of America‘s most respected chefs, shares the food memories of his childhood and his time in France in his new book “Bouchon Bakery,” which is also the name of his chain of pastry shops in the United States.


Keller is the only American chef who owns two three-Michelin-star restaurants – Per Se in New York City and The French Laundry in the Napa Valley wine region in California.






Earlier this year, Britain’s Restaurant Magazine named Per Se, which opened in 2004, the world’s sixth best restaurant. Keller also earned the magazine’s lifetime achievement award.


Like his four other books, his latest effort is a collaboration. He co-wrote it with his top pastry chefs Sebastien Rouxel and Matthew McDonald along with food writers Susie Heller, Michael Ruhlman and Amy Vogler.


The 57-year-old spoke to Reuters about the book, his pastry chefs and his place in the culinary world.


Q: Why did you collaborate with the leaders of your pastry team with this book?


A: “If you look at my other cookbooks, it’s always been a point with me to share these opportunities with those who share their skills and expertise with the general public. That was the reason why I did the book. Sebastien is one of the best pastry chefs in America. His techniques are unparalleled. I’m not trying to pretend that I’m a pastry chef by writing a book about baking and pastries. Nor am I trying to be a bread baker. I have Matthew McDonald, who is one of the best bakers in America. To be able to highlight his skills in the bread section was very important as well.”


Q: How did your time in France change your view about pastry and bread-making?


A: “When you are in France, especially in Paris, there were three or four boulangeries of different significance just on the block where I lived because they had pastry chefs with different levels of skills. You went to different ones for different things. To have a fresh baked baguette everyday was extraordinary. Anyone who lived in Paris for any length of time would say eating a fresh baguette is pretty special. Bread plays a real important part in the experience of the diners. To make sure we have the opportunity to significantly impact the experience by controlling the production and style of the bread was very important to me.”


Q: Do you have a favorite dessert?


A: “It depends on the day … There are so many things I love. I think anything that’s done really, really well. For me, that’s really something I really appreciate. I think one of the things that really resonate with the individual is that idea that eating, and eating through that experience, they have a memory. We are always trying to do something that’s good. Why put something on the menu that’s not very good?”


Q: The book emphasizes weighing ingredients over measuring with cups and spoons. Could that be difficult for home cooks?


A: “One of the things about pastry … it’s such an exact process. The most exact thing you practice is with weighing. There is an exactness to the execution, which gives you every opportunity to be successful.”


Q: French Laundry and Per Se are among two of the best restaurants in the country. Bouchon Bakery is a success. What more would you like to accomplish in the culinary world?


A: “I have accomplished today everything I wanted to accomplish, more than I ever dreamed was possible. Right now, I’m just focused on the restaurants we have and the book I just wrote. Let me enjoy this moment before you ask me what I’ll be doing tomorrow.”


Pecan Sandies for my mom (Makes 1-1/2 dozen cookies)


1 ¾ cups + 1 ½ teaspoons all-purpose flour (250 grams)


¾ cup coarsely chopped pecans (80 grams)


4 ounces unsalted butter, at room temperature (170 grams)


¾ cup + 1 ¾ teaspoons powdered sugar (90 grams)


Additional powdered sugar for dusting (optional)


1. Position the racks in the upper and lower thirds of the oven and preheat the oven to 325°F (convection) or 350°F (standard). Line two sheet pans with Silpats or parchment paper.


2. Toss the flour and pecans together in a medium bowl.


3. Place the butter in the bowl of a stand mixer fitted with the paddle attachment and mix on medium-low speed until smooth. Add the 90 grams/¾ cup plus 1¾ teaspoons powdered sugar and mix for about 2 minutes, until fluffy. Scrape down the sides and bottom of the bowl. Add the flour mixture and mix on low speed for about 30 seconds, until just combined. Scrape the bottom of the bowl to incorporate any dry ingredients that have settled there.


4. Divide the dough into 30-gram/1½-tablespoon portions, roll into balls, and arrange on the sheet pans, leaving about 1½ inches between them. Press the cookies into 2-inch disks.


5. Bake until pale golden brown, 15 to 18 minutes if using a convection oven, 22 to 25 minutes if using a standard oven, reversing the positions of the pans halfway through. (Sandies baked in a convection oven will not spread as much as those baked in a standard oven and will have a more even color.)


6. Set the pans on a cooling rack and cool for 5 to 10 minutes. Using a metal spatula, transfer the cookies to the rack to cool completely. If desired, dust with powdered sugar.


Note: The cookies can be stored in a covered container for up to 3 days.


(Reporting by Richard Leong; Editing by Patricia Reaney and James Dalgleish)


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Healthiest States in America Named






Reported by Dr. Amish Patel:


The annual America’s Health Rankings list is out, pitting U.S. states against each other in a no-holds-barred contest of health. So, how did your state fare?






For the fourth year in a row, Vermont takes the top spot as healthiest state. Applauding the state’s high rate of high school graduation and low rate of uninsured population, the report also finds that Vermont is not without its problems. Vermonters have a relatively high rate of cancer deaths and participate in binge drinking more than most states (Wisconsiners binge drink the most, Tennesseans the least). Vermont is in good company in the northeast with seven states from the region making it into the top 10.


Second place goes to Hawaii, a regular contender for first place. Since the ranking started in 1990, Hawaii has consistently ranked in the top six states. Hawaiians enjoy low rates of obesity and smoking, but have high rates of binge drinking and low birth weight babies.


Louisiana and Mississippi are tied for the least healthy state and have consistently been at the bottom of the list for the past 23 years. Both states have low rates of binge drinking, but suffer from high rates of occupational fatalities and children in poverty. These two states are in the bottom five in about half of the 24 components that make up the overall ranking, including high rates of chronic conditions like sedentary lifestyle, obesity and diabetes.


These chronic conditions are also putting the entire nation’s health most at risk. Obesity alone is the leading cause of preventable death and costs our nation about $ 200 billion each year. More than 66 million adults are obese – that’s more than one in four Americans. Colorado is the least obese and least sedentary state, in contrast to Mississippi which is the most obese and most sedentary.


“It is important to note that we are living longer, but not necessarily better,” says Jane Pennington, spokesperson from the United Health Foundation, the group responsible for the report. “Despite improvements, we still have unhealthy behavior that threatens our health status. It continues to be disappointing that we are seeing a rise in chronic illness. It doesn’t have to be that way. That is the alarm that we want to sound.”


Although smoking in the U.S. has been decreasing recently, more than 45 million Americans still smoke, according to the U.S. Centers for Disease Control and Prevention. Utah has the lowest percent of its population smoking and Kentucky has the highest.


“People should care about this report,” says Dr. Anthony Shih, executive vice president for Programs at the Commonwealth Fund. “It is clear that where you live matters in terms of overall health and it should motivate action to improve.”


States should be looking at their healthier neighbors for ways to improve.


“The relatively high performance of [fourth-ranked] Massachusetts – where a law similar to the Affordable Care Act was enacted in 2006 – may hopefully motivate other states to participate in Medicaid expansion and more aggressively implement the ACA within their own state. Successful implementation will likely raise the performance of most states,” according to Shih.


By having programs and policies that support better health, states can expect better rankings. If a state increases the tax on cigarettes or bans smoking in public places, for example, the number of smokers in that state should decrease, cutting deaths from cardiovascular disease and cancer deaths.


The statistics show that states can improve their ranking. Vermont was ranked 20 th in 1990, but steadily made improvements over the years to get where it is now.


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Thousands protest Mich. right-to-work law


LANSING, Michigan (Reuters) - More than 12,000 workers from throughout Michigan and the U.S. Midwest crowded into the state Capitol and marched outside in freezing temperatures on Tuesday as the legislature began debating a "right-to-work" law restricting unions in a stronghold of organized labor.


Michigan State Police Inspector Gene Adamczyk said the Capitol building was closed to visitors when it reached capacity of 2,200. An estimated 10,000 people demonstrated outside.


Protesters lined the railings of the inner rotunda of the Capitol in Lansing as the Republican-majority Michigan House of Representatives began debate on a law that would strike a heavy blow against unions by prohibiting them from compelling workers to be members and pay dues.


The pro-union forces earlier had chanted "Hey hey, ho ho, right-to-work has got to go," and "What's disgusting, union busting," inside the building where police had arrested eight protesters last Thursday as Republicans gave preliminary approval to the laws.


Supporters of the right-to-work legislation also were inside the Capitol and on the grounds nearby, although they were heavily outnumbered by opponents. Security was tight with police dressed in riot gear, carrying long batons and with spray canisters on their belts.


Outside, where a nearby bank sign showed the temperature at 25 degrees Fahrenheit (-4 Celsius) and light snow fell, four inflatable rats dubbed the "Rat Pack" depicted Republican Governor Rick Snyder and the party leaders who have led the right-to-work effort.


A man dressed as Santa Claus stood on the Capitol steps holding a sign saying that Republicans had stolen Christmas.


The show of force by unionized workers recalled huge rallies in Wisconsin two years ago when Republicans voted to curb public sector unions.


Several school districts in Michigan were closed as teachers went to Lansing to join the rallies.


Jen Penz, a union steward for teacher aides at Warren Consolidated Schools, said 260 teachers called in sick there, forcing schools to close in the district near Detroit.


"We're not abandoning our students. We're here to protect their future," Penz said. "We're setting a good example for them.


Ann Patnaude, deputy state director for Americans for Prosperity and a supporter of right-to-work, said many people are confused about the issue.


"The unions are still going to be around," she said. "There's still going to be collective bargaining. This is about freedom, the right to choose."


The bills under consideration by the Republican-controlled Michigan House of Representatives on Tuesday would cover private, and public sector unions, except for fire and police. Snyder has pledged to sign the bills quickly.


The right-to-work movement has been growing in the United States in recent years. Indiana earlier this year became the first state in the industrial Midwest to approve right-to-work and several other states are watching the Michigan action closely.


Michigan would become the 24th state to enact right-to-work provisions. Passage of the legislation would be a stunning blow to the power of organized labor in the United States, which has suffered a series of setbacks in recent years.


Wisconsin Republicans in 2011 passed laws severely restricting the power of public sector unions. While Wisconsin did not even attempt to pass right-to-work, the success of Republicans there in curbing powerful unions such as teachers and state workers emboldened politicians in other states to follow suit.


UNION HOTBED


Michigan is home of the heavily unionized U.S. auto industry, with some 700 manufacturing plants in the state. It is also the birthplace of the United Auto Workers, the richest U.S. labor union. Michigan has the fifth highest percentage of unionized workers in the United States at 17.5 percent.


While new Michigan laws would not be expected to have much immediate impact because existing union contracts would be preserved, they could eventually weaken the UAW, which has already seen its influence wane in negotiating with the major automakers.


Right-to-work laws typically allow workers to hold a job without being forced to join a union or pay union dues.


President Barack Obama waded into the debate during a visit to the Daimler Detroit Diesel plant in Redford, Michigan, on Monday, criticizing the Republican right-to-work effort.


"What they're really talking about is giving you the right to work for less money," Obama said.


Labor leaders such as UAW President Bob King say they were blindsided by Snyder, who last Thursday announced he was supporting right-to-work after nearly two years of saying the issue was too divisive.


King was unsuccessful in more than a week of talks with Snyder and his staff in staving off the right-to-work push by the Republicans, who will lose several seats when newly elected members take their seats in the Michigan House and Senate in January.


Detroit area is headquarters for General Motors Co, Ford Motor Co and Chrysler, which is majority owned by Fiat SpA.


(Additional reporting by Robert Carr; Editing by Greg McCune and Bill Trott)



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